Opposite of or opposite with

[Cooliegirly]

Should I say:

This is exactly the opposite with something...

or:

This is exactly the opposite of something...

[Yankee]

Hi Cooliegirly

Your sentence doesn't have enough context for me, so I'll just give you my own sentences as examples:

of: This is exactly the opposite of what we expected.

with: Working with large, multi-national companies can be incredibly complicated and bureaucratic. The situation is usually just the opposite with small companies.

Amy