"Despite of" versus "inspite of"

[Rkp]

hi,
Is it correct to use In spite of or despite in place of even though or though?

Ex: Even though he tried with his all efforts, he couldn't able to make it..

Despite his all effort ,he couldn't able to make it. ??

[Beeesneees]

Hi Rkp,
Welcome to the forums.

It's acceptable in most cases to substitute those phrases, but your example needs a little correction:
Even though he tried with all his effort('might' would be a better word here), he couldn't make it.
though he tried with all his effort(might), he couldn't make it.
Despite his every effort, he couldn't make it.
In spite of his every effort, he couldn't make it.

('might' here = power and strength)
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[sakthi_rythem@yahoo.co.in]

Nothing Can Be As Big As Business despite considering the nature what it works on.. Is this sentence correct ??

[Beeesneees]

You have unnecessary capital letters (only 'Nothing' should be capitalised).
'that' should be used instead of 'what'.

I cannot help you with the overall semantics as I'm not sure what you are trying to say. It doesn't make sense to me.
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[sakthi_rythem@yahoo.co.in]

Thanks I was actually getting this stuff printed to paste in my office wall.. Thanks man

[sakthi_rythem@yahoo.co.in]

U also need to do me some more favor.. I am starting up an ice cream business.. I have earlier planned to name as Daily-Fresh Ice creams unfortunately this particular daily-fresh is already a property of some other company can u suggest me some good names ??

[Beeesneees]

I suggest you make adjustments to your request.
First of all, to make it grammatically correct, you need to change it thus:
You also need to do me one more favor.
Then I suggest you change it further, so that it sounds less curt and demanding:
I would like you to do me one more favor.

Perhaps some of our members will have suggestions for you.
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Cheers m' dears!