Query: The speaker is very well-acquainted with the subject.

[Nessie]

1/ Don't let a good chance go...
a. on
b. off
c. by
d. over
=> I see no correct option for this test question...

2/ The speaker is very well-acquainted with the subject
=> Is the above sentence natural and correct in meaning?
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... something we never have again, I know... I guess I really really know..

Sorry seems to be the hardest word...

[Alan]

Hi Nessie,

I would suggest 'chance go by' suggesting that you shouldn't let a good chance pass without making use of it. 'Well acquainted with the subject' suggests you are familiar with it/know it well. It is acceptable.

Alan
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English as a Second Language
You can read my ESL story Word Story: Jokes

[Molly]

by

I think "pass you by" is more common then "go by".

[Yankee]

.
go by: definition 65
go by
"You can't let an opportunity like that go by - it's too good to miss."
.