"in case of whom" or "in case of which"?

[Raf]

Hello,
Which form is proper when we talk about people? "patients in case of whom or which ":?: I know that "which" is used for things, but I'm not sure about the other option either. Help!

[Mister Micawber]

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The whole structure is questionable. Please give me a sample sentence and I will judge it.
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_________________
Native English teacher at Mister Micawber's

[Raf]

The sentence goes like this:
"A long-term, safe pharmacotherapy is a method whose effectiveness has been proven in treatment of ADHD and it should be applied in children, in case of whom modification of educational methods and other therapy methods do not lead to a sufficient effect."

[Mister Micawber]

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A long-term, safe pharmacotherapy is a method whose effectiveness has been proven in the treatment of ADHD, and it should be applied in the case of children, where modification of educational methods and other therapy methods are not effective.
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_________________
Native English teacher at Mister Micawber's

[Raf]

Thank you :).