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[Dongqing3344]

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"DEPRESSION DURING PREGNANCY
Major depression is a disabling, treatable disorder that affects more than 12% of pregnant women.
Untreated depression during pregnancy has been linked to increased risks of suicide, miscarriage or preterm birth, poor fetal growth, and impaired fetal and postnatal development.
Treatment includes psychotherapy, antidepressant medication, or both; the latter is indicated for severe depression.
Data from randomized, controlled trials of antidepressants during pregnancy are lacking, but observational data suggest that selective serotonin-reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors are relatively safe.
Some adverse outcomes appear to be slightly more common in offspring of women who take antidepressants during pregnancy; these include preterm birth, neonatal adaptation difficulties, neonatal persistent pulmonary hypertension, and rare cardiac abnormalities in neonates.
Women with depression should be informed of the risks associated with antidepressant drugs as well as those associated with untreated depression, and they should be closely monitored throughout pregnancy and the first postpartum year."
----from NEMJ

[Dongqing3344]

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A 23-year-old man presented with a 1-year history of diabetes mellitus, hypertension, and hypogonadism and a weight gain of 22 kg. Abdominal striae were present on physical examination (Panel A). An endocrine evaluation showed a corticotropin-dependent hypercortisolism: his morning cortisol level after an overnight dexamethasone suppression test was 38 μg per deciliter (1048 nmol per liter) (reference range, <1.8 μg per deciliter [<49.7 nmol per liter]) and his corticotropin level was 287 pg per milliliter (63.2 pmol per liter) (reference range, <46 pg per milliliter [<10.1 pmol per liter]). Endogenous cortisol production could not be suppressed with the administration of high-dose dexamethasone and could not be stimulated with the administration of corticotropin-releasing hormone, a finding that suggested a diagnosis of Cushing's syndrome resulting from the ectopic secretion of corticotropin. Axial computed tomographic images of the chest revealed an anterior mediastinal tumor (Panel B, arrow). The mass was assumed to be a thymic carcinoid tumor and was completely resected. Histologic analysis suggested a tumor with a nested, or zellballen, pattern of growth (Panel C, left inset, hematoxylin and eosin), strong and diffuse positivity for synaptophysin (Panel C, upper-right inset), and S-100 positivity for sustentacular cells (Panel C, bottom-right inset, arrows); there was no histologic evidence of cancer. These findings confirmed a diagnosis of corticotropin-producing mediastinal paraganglioma. Postoperative levels of serum cortisol and corticotropin were low. On follow-up 3 months later, the patient showed nearly complete clinical recovery.

[Dongqing3344]

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Please listen to my recording and respond with a voice message too. Many thanks.

[Dongqing3344]

DEPRESSION DURING PREGNANCY
Major depression is a disabling, treatable disorder that affects more than 12% of pregnant women.
Untreated depression during pregnancy has been linked to increased risks of suicide, miscarriage or preterm birth, poor fetal growth, and impaired fetal and postnatal development.
Treatment includes psychotherapy, antidepressant medication, or both; the latter is indicated for severe depression.
Data from randomized, controlled trials of antidepressants during pregnancy are lacking, but observational data suggest that selective serotonin-reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors are relatively safe.
Some adverse outcomes appear to be slightly more common in offspring of women who take antidepressants during pregnancy; these include preterm birth, neonatal adaptation difficulties, neonatal persistent pulmonary hypertension, and rare cardiac abnormalities in neonates.
Women with depression should be informed of the risks associated with antidepressant drugs as well as those associated with untreated depression, and they should be closely monitored throughout pregnancy and the first postpartum year."

[Dongqing3344]

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DEPRESSION DURING PREGNANCY
Major depression is a disabling, treatable disorder that affects more than 12% of pregnant women.
Untreated depression during pregnancy has been linked to increased risks of suicide, miscarriage or preterm birth, poor fetal growth, and impaired fetal and postnatal development.
Treatment includes psychotherapy, antidepressant medication, or both; the latter is indicated for severe depression.
Data from randomized, controlled trials of antidepressants during pregnancy are lacking, but observational data suggest that selective serotonin-reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors are relatively safe.
Some adverse outcomes appear to be slightly more common in offspring of women who take antidepressants during pregnancy; these include preterm birth, neonatal adaptation difficulties, neonatal persistent pulmonary hypertension, and rare cardiac abnormalities in neonates.
Women with depression should be informed of the risks associated with antidepressant drugs as well as those associated with untreated depression, and they should be closely monitored throughout pregnancy and the first postpartum year."

[Dongqing3344]

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Please listen to my recording and respond with a voice message too. Many thanks.